Improved partial volume correction for single inversion time arterial spin labeling data

Correction of Partial Volume Effects in Arterial Spin Labeling MRI

Partial volume correction of brain perfusion estimates using the inherent signal data of time-resolved arterial spin labeling.

Quantitative perfusion MRI based on arterial spin labeling (ASL) is hampered by partial volume effects (PVEs), arising due to voxel signal cross-contamination between different compartments. To address this issue, several partial volume correction (PVC) methods have been presented. Most previous methods rely on segmentation of a high-resolution T1 -weighted morphological image volume that is co...

Estimation of Pure Gray Matter Perfusion using Pseudo-continuous Arterial Spin Labeling and Partial Volume Correction

Introduction It is well-known that the reported cerebral blood flow (CBF) values in the human brain depend on the spatial resolution of the techniques, i.e. partial volume effects (PVE) between gray matter (GM) and white matter (WM). With typical spatial resolution used in MR perfusion imaging, the number of 100% GM voxels is very small with folding cortical layers of about 2-4mm thick. Therefo...

Noninvasive assessment of arterial compliance of human cerebral arteries with short inversion time arterial spin labeling

A noninvasive method of assessing cerebral arterial compliance (AC) is introduced in which arterial spin labeling (ASL) is used to measure changes in arterial blood volume (aBV) occurring within the cardiac cycle. Short inversion time pulsed ASL (PASL) was performed in healthy volunteers with inversion times ranging from 250 to 850 ms. A model of the arterial input function was used to obtain t...

Single Pair Arterial Spin Labeling Imaging

Introduction Arterial spin labelling (ASL) is a powerful non-invasive MR technique to examine cerebral blood flow (CBF), in which the perfusion weighted signal comes from the difference between a flow sensitive (label) image and non-sensitive (control) image. Due to the small amplitude of this difference, a large number of such pairs have to be acquired to derive a sufficient level of Contrast ...